Job Hunters:   Job Board   Upload Resume   eNewsletter  
Employers:   Login   Register  
  

JOB HUNTERS:


Search for a Job

Search for a Job

Search by Job Title:

Choose a State:

..or browse job titles.



Upload Resume

Subscribe to receive eNewsletter

Our weekly e-mail newsletter is distributed at no charge and includes current healthcare news plus the latest Job Postings.
SubscribeView current eNewsletter



Upload Resume

Upload Your Resume

Upload your resume and we will forward it to employers whose search criteria best matches your qualifications.
Upload Resume



Job Search Resources

Job Search Tips & Resources

Source: University of Missouri  

Gene hunting: the power of precision medicine

MU researchers improve animal welfare by discovering genetic mutations that cause disease

Humans and animals are made up of trillions of cells, and each cell contains DNA specific to that individual. Therefore, identifying DNA that causes genetic disorders gives researchers and clinicians a better understanding of how to treat inherited diseases and possibly prevent the diseases from being passed down to future generations.

Now, researchers at the University of Missouri have located a specific mutation in the gene responsible for causing Chédiak-Higashi syndrome, a rare condition that weakens the immune system and leaves the body more vulnerable to infections. In their new study, Leslie Lyons, a professor of comparative medicine at the MU College of Veterinary Medicine, and Reuben Buckley, a postdoctoral fellow, found the answer by creating a DNA map of a domestic cat with the syndrome.

“Different treatment options target different parts of the gene, so we needed to know which part of the gene was messed up in order to target therapies to the appropriate place,” Lyons said. “Similar to finding a specific address, we knew we had the right street but we needed to find the exact house, and modern DNA sequencing helped us find it.”

Collaborating with reproduction specialists at the Cincinnati Zoo and Botanical Gardens, Lyons worked with Smokey, a 16-year-old male cat who served as the last biomedical cat model for Chédiak-Higashi syndrome before passing away. Through in vitro fertilization, Lyons was able to use semen from Smokey to resurrect the previously extinct feline disease model. Learning if cats are genetic carriers of a certain disease can be useful so that breeders are aware of which cats to avoid breeding together in order to prevent their offspring from being affected.

Lyons’ research team is also studying genetic mutations that cause other diseases, such as polycystic kidney disease, a common inherited disorder that affects hundreds of thousands of people each year and can lead to kidney failure. She highlights the value of translational medicine in her research.

Lyons' research helps improve feline health and welfare by discovering genetic mutations that cause disease. Shown here is Bonnie.

“All mammals tend to have very similar genes, so if we find out what causes a disease in cats, then whatever therapies can be used to help cats can potentially be translated to help humans suffering with the same disease,” Lyons said. “Likewise, human research can potentially be translated to help animals as well.”

In addition to translational medicine, Lyons’ research is also an example of precision medicine, or tailoring specific treatments for a patient according to their individual genetic makeup. Precision medicine will be a key component of the NextGen Precision Health Initiative by helping to accelerate medical breakthroughs for both patients in Missouri and beyond.

“Assisted reproduction mediated resurrection of a feline model for Chédiak-Higashi syndrome caused by a large duplication in LYST” was published in Scientific Reports. Funding for this project was provided by the Office of Research Infrastructure Programs/OD R24OD01092, the Winn Feline Foundation (W16-030), University of Missouri Gilbreath McLorn Endowment and donors to the 99 Lives Cat Genome Sequencing Project. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

Source: University of Missouri

Photo: University of Missouri

Pictured: Leslie Lyons, Professor of Comparative Medicine, University of Missouri, College of Veterinary Medicine




EMPLOYERS:


Post a Job

Post a Job

Special 2020
Promotional Rates

90 days online
$99

90 days online + eNewsBlast Sponsorship
$199

Post a Job
Rates & Details

Banner Advertising

Local
Post Card Advertising

Rates & Details

Weekly eNewsletterBlast E-mail Sponsorship

Weekly eNewsletterBlast E-mail Sponsorship

Rates & Details

Banner Advertising

Banner Advertising

Rates & Details


Advertisement

Copyright ©2020 HealthCareJobPosting.com
Contact us  •  Privacy Policy